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Invitrogen™ MEP1B Polyclonal Antibody
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Catalog No. PIPA583064
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100 μL
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PIPA583064 100 μL
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Catalog No. PIPA583064 Supplier Invitrogen™ Supplier No. PA583064
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MTTDNGNYFW DRPSKVGTVA LFPNGTQFRR GGGYGTSAFI THERLKSRDF IKGDDVYILL TVEDISHLNS TQIQLTPAPS VQDLCSKTTC KNDGVCTVRD GKAECRC Highest antigen sequence indentity to the following orthologs: Rat - 67%, Mouse - 68%.

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MEP1B
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Mep1b
Gene Accession No. Q16820
Gene Alias EC 3.4.24.63; Endopeptidase-2; MEP1B; Mep-1b; meprin 1 beta; meprin A; meprin A subunit beta; meprin A, beta; meprin B; meprin beta; N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta
Gene Symbols Mep1b
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MEP1B. Recombinant protein control fragment (Product #RP-102555).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4225
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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