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Invitrogen™ MEP1B Polyclonal Antibody
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Catalog No. PIPA587627
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100 μL
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PIPA587627 100 μL
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Catalog No. PIPA587627 Supplier Invitrogen™ Supplier No. PA587627
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ISGANDDQLQ WPCPWQQATM TLLDQNPDIR QRMSNQRSIT TDPFMTTDNG NYFWDRPSKV GTVALFSNGT QFRRGGGYGT SAFITHERLK SRDFIKGDDV YILLTVEDIS HLNSTQIQLT PAPSVQDLCS KTTCKNDGVC TVRDGKAECR CQSGEDWWYM GERCEKRGST RDT; Positive Samples: Mouse kidney; Cellular Location: Cell membrane, Single-pass type I membrane protein.

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MEP1B
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.63 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Mep1b
Gene Accession No. Q61847
Gene Alias EC 3.4.24.63; Endopeptidase-2; MEP1B; Mep-1b; meprin 1 beta; meprin A; meprin A subunit beta; meprin A, beta; meprin B; meprin beta; N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta
Gene Symbols Mep1b
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 480-652 of human MEP1B (NP_0059162).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17288
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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