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MERIT40 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501572587
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50-157-2587 100 μL
50-157-2588 10 μL
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Catalog No. 50-157-2587 Supplier Bethyl Laboratories, Inc Supplier No. IHC00714
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Dog, Horse, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Chinese hamst

HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes ′Lys-63′-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ′Lys-63′-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves ′Lys-63′-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the ′Lys-63′-linked deubiquitinase activity mediated by BRCC3/BRCC36.

Specifications

Antigen MERIT40
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene BABAM1
Gene Accession No. Q9NWV8
Gene Alias C19orf62, MERIT40, NBA1, BRCA1-A complex subunit MERIT40, BRISC and BRCA1-A complex member 1, mediator of RAP80 interactions and targeting subunit of 40 kDa, mediator of Rap80 interactions and targeting 40 kDa, new component of the BRCA1 A complex, new component of the BRCA1-A complex
Gene Symbols BABAM1
Host Species Rabbit
Immunogen Between 175 and 225
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29086
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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