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MERIT40 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501562782
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Catalog No. Quantity
50-156-2782 100 μL
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Catalog No. 50-156-2782 Supplier Bethyl Laboratories, Inc Supplier No. A302515A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan

HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes ′Lys-63′-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ′Lys-63′-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves ′Lys-63′-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the ′Lys-63′-linked deubiquitinase activity mediated by BRCC3/BRCC36.

Specifications

Antigen MERIT40
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene BABAM1
Gene Accession No. Q9NWV8
Gene Alias C19orf62, MERIT40, NBA1, BRCA1-A complex subunit MERIT40, BRISC and BRCA1-A complex member 1, mediator of RAP80 interactions and targeting subunit of 40 kDa, mediator of Rap80 interactions and targeting 40 kDa, new component of the BRCA1 A complex, new component of the BRCA1-A complex
Gene Symbols BABAM1
Host Species Rabbit
Immunogen Between 1 and 50
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29086
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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