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Invitrogen™ MERS Coronavirus Spike Protein S1 Monoclonal Antibody (3871)
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Catalog No. PIMA533278
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PIMA533278 1 mL
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Catalog No. PIMA533278 Supplier Invitrogen™ Supplier No. MA533278
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Description

Mouse Monoclonal Antibody

Does not cross react with the SARS Coronavirus.

The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MERS Coronavirus Spike Protein S1
Applications ELISA, Immunocytochemistry
Classification Monoclonal
Clone 3871
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.2
Gene Alias MERS Coronavirus S protein; Spike glycoprotein
Host Species Mouse
Purification Method Protein A
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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