Invitrogen™ MERTK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120917

Catalog No. PIPA5120917

Description

Positive test controls include: HepG2, Mouse spleen. The target is usually found in the following locations: Membrane, Single-pass type I membrane protein. Immunogen sequence: REEAKPYPLF PGPFPGSLQT DHTPLLSLPH ASGYQPALMF SPTQPGRPHT GNVAIPQVTS VESKPLPPLA FKHTVGHIIL SEHKGVKFNC SISVPNIYQD TTISWWKDGK ELLGAHHAIT QFYPDDEVTA IIASFSITSV QRSDNGSYIC KMKINNEEIV SDPIYIEVQG LPHFTKQPES MNVTRNTAFN LTCQAVGPPE PVNIFWVQNS SRVNEQPEKS PSVLTVPGLT EMAVFSCEAH NDKGLTVSKG VQINIKAIPS PPTEVSIRNS TAHSILISWV PGFDGYSPFR NCSIQVKEAD PLSNGSVMIF NTSALPHLYQ IKQLQALANY SIGVSCMNEI GWSAVSPWIL ASTTEGAPSV APLNVTVFLN ESSDNVDIRW MKPPTKQQDG ELVGYRISHV WQSAGISKEL LEEVGQNGSR ARISVQVHNA TCTVRIAAVT RGGVGPFSDP VKIFIPAHGW VDYAPSSTPA PGNA.

MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Specifications

• Antigen: MERTK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mertk
• Gene Alias: c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Eyk; MER; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; MGC133349; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; RP38; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyro12; Tyrosine-protein kinase Mer
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10461, 17289, 65037
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.75 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P57097, Q12866, Q60805
• Gene Symbols: Mertk
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 26-499 of human MERTK (NP_0063342).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG