MET Mouse anti-Human, Clone: OTI1E6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF805795

Catalog No. 50-166-7569

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

MET is a tyrosine kinase receptor for the hepatocyte growth factor. It is linked to functions such as cell proliferation, scattering, morphogenesis, and survival. Ligand binding at the cell surface induces autophosphorylation of MET that provides docking sites for downstream signaling molecules. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

Specifications

• Antigen: MET
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: MET
• Gene Alias: AUTS9, DFNB97, HGFR, RCCP2, c-Met
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4233
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1E6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P08581
• Gene Symbols: MET
• Immunogen: Human recombit protein fragment corresponding to amino acids 570-885 of human MET produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b