Invitrogen™ Metadherin Monoclonal Antibody (CL0397)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA534982

Catalog No. PIMA534982

Description

Immunogen sequence: RKTEPSAWSQ DTGDANTNGK DWGRSWSDRS IFSGIGSTAE PVSQSTTSDY QWDVSRNQPY IDDEWSGLNG LSSADPNSDW NAPAEEWGNW VDEERASLLK SQEPIPDDQK VSDDDKEKGE GALPTGKSKK KKKKKKKQGE DNSTAQD.

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Specifications

• Antigen: Metadherin
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: MTDH
• Gene Alias: 2610103J23Rik; 3D3; 3D3/Lyric; AEG1; AEG-1; astrocyte elevated gene 1; astrocyte elevated gene-1 protein; AV353288; D8Bwg1112e; LYRIC; LYRIC/ MTDH; LYRIC/3D3; lysine-rich CEACAM1 co-isolated protein; Metadherin; metastasis adhesion protein; MTDH; Protein LYRIC
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 92140
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: CL0397
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q86UE4
• Gene Symbols: MTDH
• Immunogen: Recombinant Protein corresonding to Human Metadherin.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov