Invitrogen™ H4R3me1 Recombinant Rabbit Monoclonal Antibody (RM195)

Catalog No.	Quantity
PIMA524689	100 μg

Catalog No. PIMA524689 Supplier Invitrogen™ Supplier No. MA524689

Description

Rabbit Recombinant Monoclonal Antibody

This antibody reacts to Histone H4 monomethylated at Arginine 3 (R3me1). No cross reactivity with unmodified Arginine 3, asymmetric or symmetric dimethylated Arginine 3, and citrullinated Arginine 3 in Histone H4. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Specifications

• Antigen: H4R3me1
• Applications: ELISA, Western Blot, Luminex, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: RM195
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 1% BSA and 0.09% sodium azide; pH 7.2-7.4
• Gene: H4C1
• Gene Accession No.: P62805
• Gene Alias: FO108; H4; H4 histone family, member A; H4 histone family, member I; H4 histone family, member J; H4 histone family, member M; H4 histone family, member N; H4 histone, family 2; H4 R3; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/j; H4/K; H4/M; H4/N; H4/O; H4/p; H4-12; H4-16; H4-53; H4Arg3me; H4Arg3me1; H4C1; H4c11; H4c12; H4C13; H4C14; H4C15; H4c2; H4c3; H4c4; H4C5; H4c6; H4c8; H4C9; H4f16; H4F2; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; H4M; H4R3; H4R3me; HIST1H4; HIST1H4A; Hist1h4b; HIST1H4C; Hist1h4d; HIST1H4E; HIST1H4F; HIST1H4H; Hist1h4i; HIST1H4J; Hist1h4k; HIST1H4L; Hist1h4m; Hist2h4; Hist2h4a; HIST2H4B; Hist4h4; histone 1, H4a; histone 1, H4b; histone 1, H4e; histone 1, H4i; histone 2, H4; histone 2, H4a; Histone 4; Histone 4 family, member M; histone 4, H4; histone cluster 1, H4a; histone cluster 1, H4b; histone cluster 1, H4e; histone cluster 1, H4i; histone cluster 2, H4; histone cluster 2, H4a; Histone Cluster 4; histone cluster 4, H4; histone family member; histone H4; Histone H4A; Histone H4R3me1; histone IV, family 2; methyl Histone 3; methyl Histone H3; Methyl-H4 Arg3; Methyl-H4 R3; Methyl-Histone H4 Arg3; Methyl-Histone H4 R3; Mono-methyl H4; Mono-methyl Histone H4; X04652
• Gene Symbols: H4-16, H4C1, H4C11, H4C14, H4C2, H4C5, H4C9, HIST1H4A
• Host Species: Rabbit
• Immunogen: Monomethyl -peptide corresponding to the Monomethyl -Histone H4 (Arg3).
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 121504, 8294, 8359, 8363, 8366, 8367, 8370
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG