Invitrogen™ METRNL Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA554888

Catalog No. PIPA554888

Description

Immunogen sequence: QYSSDRCSWK GSGLTHEAHR KEVEQVYLRC AAGAVEWMYP TGALIVNLRP NTFSPARHLT VCIRSFTDSS Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 86%.

Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.

Specifications

• Antigen: METRNL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: METRNL
• Gene Alias: 9430048M07Rik; BC019776; cometin; meteorin like, glial cell differentiation regulator; meteorin, glial cell differentiation regulator-like; meteorin-like protein; METRNL; Subfatin
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 284207
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q641Q3
• Gene Symbols: METRNL
• Immunogen: Recombinant protein corresponding to Human METRNL. Recombinant protein control fragment (Product #RP-93447).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG