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Invitrogen™ METRNL Polyclonal Antibody
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Catalog No. PIPA554888
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100 μL
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PIPA554888 100 μL
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Catalog No. PIPA554888 Supplier Invitrogen™ Supplier No. PA554888
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QYSSDRCSWK GSGLTHEAHR KEVEQVYLRC AAGAVEWMYP TGALIVNLRP NTFSPARHLT VCIRSFTDSS Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 86%.

Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
TRUSTED_SUSTAINABILITY

Specifications

Antigen METRNL
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene METRNL
Gene Accession No. Q641Q3
Gene Alias 9430048M07Rik; BC019776; cometin; meteorin like, glial cell differentiation regulator; meteorin, glial cell differentiation regulator-like; meteorin-like protein; METRNL; Subfatin
Gene Symbols METRNL
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human METRNL. Recombinant protein control fragment (Product #RP-93447).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 284207
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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