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Invitrogen™ MFN1 Polyclonal Antibody
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Catalog No. PIPA597281
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100 μL
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PIPA597281 100 μL
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Catalog No. PIPA597281 Supplier Invitrogen™ Supplier No. PA597281
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Description

Rabbit Polyclonal Antibody

Positive Samples: A-549, LO2, SW480, Mouse liver, Mouse kidney; Cellular Location: Cytoplasm, Mitochondrion outer membrane, Multi-pass membrane protein Immunogen sequence: YGALYLYERL SWTTHAKERA FKQQFVNYAT EKLRMIVSST SANCSHQVKQ QIATTFARLC QQVDITQKQL EEEIARLPKE IDQLEKIQNN SKLLRNKAVQ LENELENFTK QFLPSSNEES.

Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MFN1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 3.78 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene MFN1
Gene Accession No. Q811U4, Q8IWA4, Q8R4Z9
Gene Alias 2310002F04Rik; 6330416C07Rik; D3Ertd265e; DKFZp762F247; EC 3.6.5; FLJ20693; Fzo homolog; Fzo1b; hfzo1; hfzo2; HR2; Mfn1; MFN2; MGC41806; mitochondrial mitofusin 1; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO1B; mitochondrial transmembrane GTPase FZO-2; mitofusin 1; mitofusin 2; mitofusin-1; mKIAA4032; putative transmembrane GTPase; transmembrane GTPase MFN1
Gene Symbols MFN1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 622-741 of human Mitofusin-1/MFN1 (NP_2849412).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 192647, 55669, 67414
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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