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Invitrogen™ MFN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA544826

Catalog No. PIPA544826


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Description

Description

Peptide sequence: SVINAMLWDK VLPSGIGHIT NCFLSVEGTD GDKAYLMTEG SDEKKSVKTV Sequence homology: Cow: 100%; Dog: 100%; Horse: 92%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%.

Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

MFN1
Polyclonal
Unconjugated
MFN1
2310002F04Rik; 6330416C07Rik; D3Ertd265e; DKFZp762F247; EC 3.6.5; FLJ20693; Fzo homolog; Fzo1b; hfzo1; hfzo2; HR2; Mfn1; MFN2; MGC41806; mitochondrial mitofusin 1; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO1B; mitochondrial transmembrane GTPase FZO-2; mitofusin 1; mitofusin 2; mitofusin-1; mKIAA4032; putative transmembrane GTPase; transmembrane GTPase MFN1
Rabbit
Affinity chromatography
RUO
55669, 67414
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide
Q811U4, Q8IWA4
MFN1
Synthetic peptide directed towards the N-terminal of human MFN1 (aa 90-139).
100 μL
Primary
Human, Mouse
Antibody
IgG
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