Invitrogen™ MFN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120367

Catalog No. PIPA5120367

Description

Positive test controls include: PC-3, Mouse kidney, Rat kidney. The target is usually found in the following locations: Cytoplasm, Mitochondrion outer membrane, Multi-pass membrane protein. Immunogen sequence: MAETVSPLKH FVLAKKAITA IFGQLLEFVT EGSHFVEATY RNPELDRIAS EDDLVEIQGY RNKLAVIGEV LSRRHMKVAF FGRTSSGKSS VINAMLWDKV.

Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.

Specifications

• Antigen: MFN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MFN1
• Gene Alias: 2310002F04Rik; 6330416C07Rik; D3Ertd265e; DKFZp762F247; EC 3.6.5; FLJ20693; Fzo homolog; Fzo1b; hfzo1; hfzo2; HR2; Mfn1; MFN2; MGC41806; mitochondrial mitofusin 1; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO1B; mitochondrial transmembrane GTPase FZO-2; mitofusin 1; mitofusin 2; mitofusin-1; mKIAA4032; putative transmembrane GTPase; transmembrane GTPase MFN1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 192647, 55669, 67414
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q811U4, Q8IWA4, Q8R4Z9
• Gene Symbols: MFN1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of mouse MFN1 (NP_077162.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG