MFN1 Mouse anti-Mouse, Rat, Clone: 11E9-1H12, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA524789
DescriptionMitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.
|PBS with 0.02% sodium azide; pH 7.4|
|DKFZp762F247, EC 3.6.5, EC 3.6.5.-, FLJ20693, Fzo homolog, hfzo1, hfzo2, MGC41806, mitochondrial transmembrane GTPase Fzo-1, mitochondrial transmembrane GTPase FZO-2, mitofusin 1, mitofusin-1, putative transmembrane GTPase, Transmembrane GTPase MFN1|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
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