Invitrogen™ MFN2 Monoclonal Antibody (N153/5), FITC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA545670

Catalog No. PIMA545670

Description

Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1. 1 μg/mL of MA5-45670 was sufficient for detection of Mitofusin-2 in 20 μg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 90kDa. No cross-reactivity against Mitofusin-1. This antibody was formerly sold as clone S153-5.

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Specifications

• Antigen: MFN2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS, 9.1 mM sodium bicarbonate with 640.91 mM DMSO, 136.36 mM ethanolamine and no preservative; pH 7.4
• Gene Accession No.: O95140, Q80U63, Q8R500
• Gene Symbols: MFN2
• Immunogen: Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: N153/5
• Conjugate: FITC
• Gene: MFN2
• Gene Alias: CMT2A; CMT2A2; CPRP 1; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; HSG protein; hyperplasia suppressor; hypertension related protein 1; hypertension-related protein; hypertension-related protein 1; Kiaa0214; LOW QUALITY PROTEIN: mitofusin-2; Marf; MFN 2; MFN2; mg:cb01g09; Mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; mitofusin 2; Mitofusin2; mitofusin-2; si:dkeyp-104h9.2; Transmembrane GTPase MFN2; wu:fb79a11
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 170731, 64476, 9927
• Content And Storage: 4°C, store in dark
• Form: Liquid