Invitrogen™ MFN2 Monoclonal Antibody (N153/5)

Catalog No.	Quantity
PIMA527647	100 μg

Catalog No. PIMA527647 Supplier Invitrogen™ Supplier No. MA527647

Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-27647 was sufficient for detection of Mitofusin-2 in 20 μg of mouse cardiac mitochondrial lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 90kDa. No cross-reactivity against Mitofusin-1. This antibody was formerly sold as S153-5.

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Specifications

• Antigen: MFN2
• Applications: Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: N153/5
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
• Gene: MFN2
• Gene Accession No.: O95140, Q80U63, Q8R500
• Gene Alias: CMT2A; CMT2A2; CPRP 1; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; HSG protein; hyperplasia suppressor; hypertension related protein 1; hypertension-related protein; hypertension-related protein 1; Kiaa0214; LOW QUALITY PROTEIN: mitofusin-2; Marf; MFN 2; MFN2; mg:cb01g09; Mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; mitofusin 2; Mitofusin2; mitofusin-2; si:dkeyp-104h9.2; Transmembrane GTPase MFN2; wu:fb79a11
• Gene Symbols: MFN2
• Host Species: Mouse
• Immunogen: Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2. Rat: 97% identity (226/231 amino acids identical). Human: 92% identity (214/231 amino acids identical) ~55% identity with Mitofusin-1.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 170731, 64476, 9927
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a