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Tocris Bioscience™ MG 132
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Catalog No. 17485
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Proteasome and calpain inhibitor. Inhibits NF-κB activation

MG 132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM). MG 132 inhibits TNF-α-induced NF-κB activation and IκBα degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro. MG 132 inhibits SARS-CoV-2 Mpro in vitro (IC50 = 3.9 μM) and inhibits viral replication. Also enhances adeno-associated viral transduction efficiency of human cell lines by around 50-fold.

Specifications

CAS 133407-82-6
Quantity 5 mg
Product Type MG 132
Purity >95%
Molecular Weight (g/mol) 475.63
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