Invitrogen™ mGluR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522800

Catalog No. PIPA522800

Description

Suggested positive control: antigen standard for GRIA1 (transient overexpression lysate). This antibody is reactive against Human, Mouse, Rat.

Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.

Specifications

• Antigen: mGluR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Grm1
• Gene Alias: 4930455H15Rik; ENSMUSG00000075319; G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; glutamate metabotropic receptor 1; glutamate receptor; glutamate receptor, metabotropic 1; Gm10828; GPRC1A; GRM1; GRM1A; Metabotropic glutamate receptor 1; MGLU1; MGLUR1; mGluR1a; nmf373; PPP1R85; protein phosphatase 1, regulatory subunit 85; rcw; SCAR13; wobl
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14816, 24414, 2911
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P23385, P97772, Q13255
• Gene Symbols: Grm1
• Immunogen: Synthetic peptide comprising internal residues of the human metabotropic GluR1 alpha protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG