Invitrogen™ mGluR1 Polyclonal Antibody

Catalog No.	Quantity
PI720274	100 μg

Catalog No. PI720274 Supplier Invitrogen™ Supplier No. 720274

Description

Rabbit Polyclonal Antibody

These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature. This antibody is predicted to react with Monkey, Horse, Dog and Rat.

Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.

Specifications

• Antigen: mGluR1
• Applications: Immunohistochemistry
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.1% BSA, 30% glycerol and 0.09% sodium azide; pH 7.2
• Gene: Grm1
• Gene Accession No.: Q13255
• Gene Alias: 4930455H15Rik; ENSMUSG00000075319; G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A; glutamate metabotropic receptor 1; glutamate receptor; glutamate receptor, metabotropic 1; Gm10828; GPRC1A; GRM1; GRM1A; Metabotropic glutamate receptor 1; MGLU1; MGLUR1; mGluR1a; nmf373; PPP1R85; protein phosphatase 1, regulatory subunit 85; rcw; SCAR13; wobl
• Gene Symbols: Grm1
• Host Species: Rabbit
• Immunogen: Peptide corresponding to Human GRM1 (aa 143-155).
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2911
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG