Invitrogen™ mGluR2/mGluR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA130151

Catalog No. PIPA130151

Description

PA1-30151 detects mGluR2 + mGluR3 from rat samples. Sequence is 100% conserved between mGluR2 and mGluR3. Predicted to react with human and mouse.

The mGluR proteins (metabotropic Glutamate Receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic Glutamate Receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.

Specifications

• Antigen: mGluR2/mGluR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Grm2
• Gene Alias: 0710001G23Rik; 4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member C; GLUR2; GLUR3; glutamate metabotropic receptor 2; glutamate metabotropic receptor 3; glutamate receptor; glutamate receptor homolog; glutamate receptor, metabotropic 2; glutamate receptor, metabotropic 3; Gprc1b; GPRC1C; GRM2; Grm3; M mGlu3; Metabotropic glutamate receptor 2; metabotropic glutamate receptor 3; mGlu2; mGlu3; mGluR2; MGLUR3; mGluR7
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 24415, 24416
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P31421, P31422
• Gene Symbols: Grm2, Grm3
• Immunogen: Rat mGlurR2/3 residues 860-872 (NGREVVDSTTSSL).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov