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mGLuR2 Rabbit anti-Human, Rat, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  LIFE TECHNOLOGIES 702592

Encompass

Catalog No. 70-259-2


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Description

Description

This antibody is predicted to react with Monkey, Rabbit, Bovine. Recombit rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombit rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
Specifications

Specifications

mGLuR2
Recombinant Monoclonal
0.5 mg/ml
PBS with 0.09% sodium azide; pH 7.4
P31421, Q14416
Glutamate Metabotropic Receptor 2
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
24415, 2912
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
15H9L5
Unconjugated
GRM2
Liquid
GRM2
Peptide corresponding to human mGLUR2 [ aa429-aa444]
Protein A
RUO
Antibody
Monoclonal
Human, Rat
SDS
Documents
Product Certifications
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