Invitrogen™ mGluR2 Recombinant Superclonal™ Antibody (15HCLC)

Catalog No.	Quantity
71-162-3	100 μg

Catalog No. 71-162-3 Supplier Invitrogen™ Supplier No. 711623

Description

Rabbit Recombinant Superclonal Antibody

This antibody is predicted to react with Monkey, Rabbit, Bovine. Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called 'Recombinant polyclonal antibody', this product is now rebranded as 'Recombinant Superclonal™ antibody'. The physical product and the performance remain unchanged.

Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.

Specifications

• Antigen: mGluR2
• Applications: Immunocytochemistry
• Classification: Recombinant Superclonal
• Clone: 15HCLC
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.2-7.4
• Gene: GRM2
• Gene Accession No.: Q14416
• Gene Alias: 4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; GLUR2; glutamate metabotropic receptor 2; glutamate receptor; glutamate receptor homolog; glutamate receptor, metabotropic 2; GPRC1B; Grm2; M mGlu2; Metabotropic; Metabotropic glutamate receptor 2; mGlu2; MGLUR2; mGluR7
• Gene Symbols: GRM2
• Host Species: Rabbit
• Immunogen: Peptide corresponding to human mGluR2 [ aa429-aa444].
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2912
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

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