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Invitrogen™ mGluR2 Recombinant Rabbit Monoclonal Antibody (JJ091-09)
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Catalog No. PIMA542460
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100 μL
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PIMA542460 100 μL
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Catalog No. PIMA542460 Supplier Invitrogen™ Supplier No. MA542460
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: SH-SY-5Y, SW480, Hela, mouse brain tissue. Subcellular Location: Cell membrane, Cell junction, Cell projection.

Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen mGluR2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone JJ091-09
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 40% glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
Gene GRM2
Gene Accession No. P31421, Q14416, Q14BI2
Gene Alias 4930441L02Rik; G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; GLUR2; glutamate metabotropic receptor 2; glutamate receptor; glutamate receptor homolog; glutamate receptor, metabotropic 2; GPRC1B; Grm2; M mGlu2; Metabotropic; Metabotropic glutamate receptor 2; mGlu2; MGLUR2; mGluR7
Gene Symbols GRM2
Host Species Rabbit
Immunogen Recombinant protein within human mGluR2 aa 750-872.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 108068, 24415, 2912
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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