Invitrogen™ mGluR3 Monoclonal Antibody (7A5A6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA531750

Catalog No. PIMA531750

Description

MA5-31750 has been tested in indirect ELISA.

Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.

Specifications

• Antigen: mGluR3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q14832
• Gene Symbols: GRM3
• Immunogen: Purified recombinant fragment of human GRM3 (AA: extra 433-576) expressed in E. coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 7A5A6
• Conjugate: Unconjugated
• Gene: GRM3
• Gene Alias: 0710001G23Rik; G protein-coupled receptor, family C, group 1, member C; GLUR3; glutamate metabotropic receptor 3; glutamate receptor; glutamate receptor, metabotropic 3; Gprc1c; GRM3; M mGlu3; Metabotropic glutamate receptor 3; mGlu3; mGluR3
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 2913
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid