Invitrogen™ mGluR7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115575

Catalog No. PIPA5115575

Description

Antibody detects endogenous levels of total mGluR7.

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: mGluR7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GRM7
• Gene Alias: 6330570A01Rik; BB176677; C030018L03; E130018M02Rik; FLJ40498; G protein-coupled receptor GRM7; G protein-coupled receptor, family C, group 1, member G; GLUR7; glutamate metabotropic receptor 7; glutamate receptor; glutamate receptor, metabotropic 7; Gpr1g; Gprc1g; GRM7; Metabotropic glutamate receptor 7; metabotropic glutamate receptor mGluR7; metabotropic glutamate receptor subtype 7b; MGLU7; mGlu7a receptor; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 108073, 2917, 81672
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P35400, Q14831, Q68ED2
• Gene Symbols: GRM7
• Immunogen: A synthesized peptide derived from human GRM7(Accession Q14831), corresponding to amino acid residues S874-I915.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG