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Invitrogen™ mGluR8 Polyclonal Antibody
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Catalog No. PIPA533830
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50 μg
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Catalog No. Quantity
PIPA533830 50 μg
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Catalog No. PIPA533830 Supplier Invitrogen™ Supplier No. PA533830
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Description

Rabbit Polyclonal Antibody

mGluR8 Polyclonal Antibody for ICC/IF, IHC (P)

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
TRUSTED_SUSTAINABILITY

Specifications

Antigen mGluR8
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene GRM8
Gene Accession No. O00222, P47743, P70579
Gene Alias A230002O04; FLJ41058; G protein coupled receptor, family C, group 1, member H; G protein-coupled receptor family C group 1 member H; G protein-coupled receptor, family C, group 1, member H; GLUR8; glutamate metabotropic receptor 8; glutamate receptor; glutamate receptor, metabotropic 8; Gprc1h; Grm8; M mGlu8; Metabotropic glutamate receptor 8; metabotropic glutamate receptor subtype 8b; MGC126724; mGlu8; mGlur; mGluR8; mGluR8b
Gene Symbols GRM8
Host Species Rabbit
Immunogen Synthetic 16 amino acid peptide from N-terminal extracellular domain of human GRM8 / MGLUR8.
Purification Method Antigen affinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100071655, 100344818, 100758817, 101108742, 14823, 2918, 427853, 482270, 60590
Target Species Human, Mouse, Rat, Canine, Rabbit, Monkey, Sheep, Hamster, Horse, Chicken, Bat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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