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MGMT Monoclonal Antibody (MT 3.1), Biotin, Invitrogen™

Catalog No. PIMA513503
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500 μL
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Catalog No. Quantity
PIMA513503 500 μL
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Catalog No. PIMA513503 Supplier Thermo Scientific Supplier No. MA513503

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Mouse Monoclonal Antibody

MA5-13503 targets MGMT (O-methylguanine-DNA methyltransferase) in FACS, IHC (P), ICC/IF and WB applications and shows reactivity with Human samples. The MA5-13503 immunogen is purified recombinant human MGMT protein.

O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytostatic activity of chemotherapeutic alkylating agents. This protein is also effective in protecting normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT's ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in highly variable amounts, depending upon the cell and tissue type, species, and cellular growth characteristics. In addition, MGMT activity varies among groups of tumors and within a particular type of tumor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MGMT
Applications Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone MT 3.1
Concentration 0.2 mg/mL
Conjugate Biotin
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene MGMT
Gene Accession No. P16455
Gene Alias 0-6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase; Agat; AGT; AI267024; methylated DNA protein cysteine methyltransferase; methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; MGMT; O(6)-alkylguanine-DNA alkyltransferase; O-6-alkylguanine-DNA alkyltransferase; O6-alkylguanine-DNA alkyltransferase; O-6-methylguan; O6-methylguanine-DNA methyltranferase; O-6-methylguanine-DNA methyltransferase; O6-methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase
Gene Symbols MGMT
Host Species Mouse
Immunogen Purified recombinant human MGMT protein
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4255
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1
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