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MilliporeSigma™ MGMT, Mouse, Alexa Fluor 488, Clone: MT3.1,

Catalog No. MAB16200AF4 Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Alexa Fluor 488
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Catalog No. Quantity Conjugate
MAB16200AF4 100 μL Alexa Fluor 488
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Catalog No. MAB16200AF4 Supplier MilliporeSigma™ Supplier No. MAB16200AF488

Description

Mouse Monoclonal Antibody

Methylated-DNA-protein-cysteine methyltransferase (EC 2.1.1.63; UniProt P16455; also known as 6-O-methylguanine-DNA methyltransferase, GATase, MGMT, O-6-methylguanine-DNA-alkyltransferase) is encoded by the MGMT gene (Gene ID 4255) in human. MGMT is a DNA repair enzyme that removes alkyl groups from O6-guanine and plays a fundamental role in maintaining genomic integrity. MGMT converts the naturally occurring mutagenic DNA lesion O6-methylguanine back to guanine, thereby prevents mismatch and errors during DNA replication and transcription. MGMT expression level correlates with cellular resistance to alkylnitrosoureas, compounds that induce O6-alkylguanine lesions. MGMT transcription is negatively regulated via promoter methylation, MGMT promoter methylation level is reported to correclate with the survival rate of glioblastoma patients receiving treatment with alkylating agents.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MGMT
Applications Immunocytochemistry
Classification Monoclonal
Clone MT3.1
Concentration Please refer to lot specific datasheet.
Conjugate Alexa Fluor 488
Formulation Purified mouse IgG1 Alexa Fluor™ 488 conjugate in PBS with 1.5% BSA and 0.05% Sodium Azide.
Gene MGMT
Gene Accession No. P16455
Host Species Mouse
Immunogen GATase purified from CEM-CCRF human leukemic lymphoblasts (Harris, L.C., et al. (1996). Cancer Res. 56(9):2029-2032; Brent, T.P., et al. (1990). Cancer Res. 50(1):58-61).
Purification Method Protein A Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Epigenetics & Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NM_002412.2
Test Specificity Clone MT 3.1 detected p53 expression-dependent MGMT downregulation in IMR90 cells (Harris, L.C., et al. (1996). Cancer Res. 56(9):2029-2032).
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG1
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For Research Use Only. Not for use in diagnostic procedures.

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