MGMT Mouse anti-Human, Clone: OTI2E2, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF809129

Catalog No. 50-166-9288

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytostatic activity of chemotherapeutic alkylating agents. This protein is also effective in protecting normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT′s ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in highly variable amounts, depending upon the cell and tissue type, species, and cellular growth characteristics. In addition, MGMT activity varies among groups of tumors and within a particular type of tumor.

Specifications

• Antigen: MGMT
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: MGMT
• Gene Alias: O-6-methylguanine-DNA methyltransferase
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4255
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2E2
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P16455
• Gene Symbols: MGMT
• Immunogen: Full length human recombit protein of human MGMT produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1