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MGMT Mouse anti-Human, Clone: UMAB56, lyophilized, UltraMAB™
SDP

Catalog No. 501685155
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100 μg
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Catalog No. Quantity
50-168-5155 100 μg
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Catalog No. 50-168-5155 Supplier OriGene Supplier No. UM800007CF
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytostatic activity of chemotherapeutic alkylating agents. This protein is also effective in protecting normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT′s ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in highly variable amounts, depending upon the cell and tissue type, species, and cellular growth characteristics. In addition, MGMT activity varies among groups of tumors and within a particular type of tumor.

Specifications

Antigen MGMT
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone UMAB56
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene MGMT
Gene Accession No. P16455
Gene Alias O-6-methylguanine-DNA methyltransferase
Gene Symbols MGMT
Host Species Mouse
Immunogen Full length human recombit protein of human MGMT produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4255
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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