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Invitrogen™ MIA Polyclonal Antibody
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Catalog No. PIPA5143011
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100 μg
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PIPA5143011 100 μg
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Catalog No. PIPA5143011 Supplier Invitrogen™ Supplier No. PA5143011
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Description

Goat Polyclonal Antibody

Additional Information: The immunizing peptide represents the N terminus of the mature protein. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.

Tumorigenesis is a process that is mediated by a network of membrane, cytosolic and nuclear associated factors, which regulate proliferation and cell-matrix interaction through signaling cascades. The phenotype of malignant melanomas in vivo depends on the global expression of stimulatory or inhibitory factors generated in both the tumors cells and their environment. One example, Melanoma inhibitory activity (cartilage-derived retinoic acid-sensitive protein (CD-RAP), MIA) is a Src homology 3 (SH3)-like domain containing protein that is secreted from chondrocytes and malignant melanoma cells. MIA is translated as a 131-amino acid pro-form and processed into a mature 107-amino acid protein after cleavage of a secretion signal. MIA is expressed during chondrogenesis and in mature chondrocytes, suggesting that MIA is necessary for normal cartilage cell phenotype. MIA mRNA is present in carcinomas of the colon, ovary, kidney, and head/neck, and may represent a marker to monitor melanomic activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MIA
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene MIA
Gene Accession No. Q16674
Gene Alias cartilage derived retinoic acid sensitive protein; cartilage-derived retinoic acid-sensitive protein; Cdrap; CD-RAP; melanoma inhibitory activity; melanoma inhibitory activity 1; melanoma inhibitory activity protein; melanoma inhibitory activity/condrocyte-derived retinoic acid sensitive protein homolog (MIA/CD-RAP); melanoma-derived growth regulatory protein; melanoma-inhibitory-activity; MIA; Mia1
Gene Symbols MIA
Host Species Goat
Immunogen Peptide with sequence PKLADRKLCADQE (aa 28-40).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8190
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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