Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Invitrogen™ MIB1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA553924
Description
Immunogen sequence: LDLEIVQSLQ HGHGGWTDGM FETLTTTGTV CGIDEDHDIV VQYPSGNRWT FNPAVLTKAN IVRSGDAAQG AEGGTSQFQV GDLVQVCYDL ERIKLLQRGH GEWAEAM Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
Specifications
MIB1 | |
Polyclonal | |
Unconjugated | |
MIB1 | |
DAPK-interacting protein 1; DAPK-interacting protein-1; DIP1; DIP-1; E3 ubiquitin-protein ligase MIB1; E430019M12Rik; KIAA1323; LVNC7; MIB; MIB1; Mind bomb homolog 1; mind bomb-1; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1; mindbomb homolog 1 (Drosophila); mKIAA1323; RING-type E3 ubiquitin transferase MIB1; skeletrophin; ubiquitin ligase mind bomb; zinc finger ZZ type with ankyrin repeat domain protein 2; ZZANK2; ZZZ6 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
57534 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Immunocytochemistry | |
0.2 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q86YT6 | |
MIB1 | |
Recombinant protein corresponding to Human MIB1. Recombinant protein control fragment (Product #RP-92400). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction