Invitrogen™ MIB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595570

Catalog No. PIPA595570

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human U87 whole cell, rat liver tissue, rat brain tissue, mouse liver tissue, mouse brain tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

Specifications

• Antigen: MIB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MIB1
• Gene Alias: DAPK-interacting protein 1; DAPK-interacting protein-1; DIP1; DIP-1; E3 ubiquitin-protein ligase MIB1; E430019M12Rik; KIAA1323; LVNC7; MIB; MIB1; Mind bomb homolog 1; mind bomb-1; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1; mindbomb homolog 1 (Drosophila); mKIAA1323; RING-type E3 ubiquitin transferase MIB1; skeletrophin; ubiquitin ligase mind bomb; zinc finger ZZ type with ankyrin repeat domain protein 2; ZZANK2; ZZZ6
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 225164, 307594, 57534
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: ELISA, Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene Accession No.: Q80SY4, Q86YT6
• Gene Symbols: MIB1
• Immunogen: E.coli-derived human Mib1 Mindbomb recombinant protein (Position: H465-E732).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG