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Invitrogen™ MIB1 Polyclonal Antibody
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Catalog No. PIPA597126
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100 μL
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PIPA597126 100 μL
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Catalog No. PIPA597126 Supplier Invitrogen™ Supplier No. PA597126
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DSEGDTPLHD AISKKRDDIL AVLLEAGADV TITNNNGFNA LHHAALRGNP SAMRVLLSKL PRPWIVDEKK DDGYTALHLA ALNNHVEVAE LLVHQGNANL DIQNVNQQTA LHLAVERQHT QIVRLLVRAG AKLDIQDKDG DTPLHEALRH HTLSQLRQLQ DMQDVGKVDA AWEPSKNTLI MGLGTQGAEK KSAASIACFL AANGADLSIR NKKGQSPLDL CPDPNLCKAL AKCHKEKVSG QVGSRSPSMI SNDSETLEEC MVCSDMKRDT LFGPCGHIAT CSLCSPRVKK CLICKEQVQS R; Positive Samples: U-87MG, A-549, HepG2, Mouse stomach, Mouse lung, Mouse kidney, Rat testis; Cellular Location: Cell membrane, Cytoplasm, centriolar satellite, centrosome, cytoskeleton, microtubule organizing center.

MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MIB1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.31 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene MIB1
Gene Accession No. Q80SY4, Q86YT6
Gene Alias DAPK-interacting protein 1; DAPK-interacting protein-1; DIP1; DIP-1; E3 ubiquitin-protein ligase MIB1; E430019M12Rik; KIAA1323; LVNC7; MIB; MIB1; Mind bomb homolog 1; mind bomb-1; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1; mindbomb homolog 1 (Drosophila); mKIAA1323; RING-type E3 ubiquitin transferase MIB1; skeletrophin; ubiquitin ligase mind bomb; zinc finger ZZ type with ankyrin repeat domain protein 2; ZZANK2; ZZZ6
Gene Symbols MIB1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 560-860 of human MIB1/DIP1 (NP_0658251).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 225164, 307594, 57534
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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