Invitrogen™ MIB1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142904

Catalog No. PIPA5142904

Description

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

Specifications

• Antigen: MIB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MIB1
• Gene Alias: DAPK-interacting protein 1; DAPK-interacting protein-1; DIP1; DIP-1; E3 ubiquitin-protein ligase MIB1; E430019M12Rik; KIAA1323; LVNC7; MIB; MIB1; Mind bomb homolog 1; mind bomb-1; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1; mindbomb homolog 1 (Drosophila); mKIAA1323; RING-type E3 ubiquitin transferase MIB1; skeletrophin; ubiquitin ligase mind bomb; zinc finger ZZ type with ankyrin repeat domain protein 2; ZZANK2; ZZZ6
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 57534
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q86YT6
• Gene Symbols: MIB1
• Immunogen: Peptide with sequence C-DKDNTNVNADVQKLQ.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG