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Invitrogen™ MIB1 Recombinant Rabbit Monoclonal Antibody (9Q4N9)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA538060
Description
Positive Samples: 293T, K-562, U-87MG, Mouse lung, Mouse testis, Mouse brain, Rat brain Immunogen sequence: MSNSRNNRVM VEGVGARVVR GPDWKWGKQD GGEGHVGTVR SFESPEEVVV VWDNGTAANY RCSGAYDLRI LDSAPTGIKH DGTMCDTCRQ QPIIGIRWKC.
MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
Specifications
MIB1 | |
Recombinant Monoclonal | |
0.45 mg/mL | |
PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q80SY4, Q86YT6 | |
MIB1 | |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MIB1/DIP1 (Q86YT6). | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
ELISA, Western Blot | |
9Q4N9 | |
Unconjugated | |
MIB1 | |
DAPK-interacting protein 1; DAPK-interacting protein-1; DIP1; DIP-1; E3 ubiquitin-protein ligase MIB1; E430019M12Rik; KIAA1323; LVNC7; MIB; MIB1; Mind bomb homolog 1; mind bomb-1; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1; mindbomb homolog 1 (Drosophila); mKIAA1323; RING-type E3 ubiquitin transferase MIB1; skeletrophin; ubiquitin ligase mind bomb; zinc finger ZZ type with ankyrin repeat domain protein 2; ZZANK2; ZZZ6 | |
Rabbit | |
Affinity chromatography | |
RUO | |
225164, 307594, 57534 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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