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Invitrogen™ MICA Monoclonal Antibody (A4C5)
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Catalog No. PIMA542525
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100 μL
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PIMA542525 100 μL
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Catalog No. PIMA542525 Supplier Invitrogen™ Supplier No. MA542525
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Description

Mouse Monoclonal Antibody

Positive Control: MCF-7 cell lysate, Hela cell lysate. Subcellular Location: Cell membrane, Cytoplasm, Membrane.

Major histocompatibility complex (MHC) class I proteins are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. A related family, termed the MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. Both MICA and MICB mRNA are widely expressed in normal tissues, with MICA being present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MICA
Applications Western Blot
Classification Monoclonal
Clone A4C5
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene MICA
Gene Accession No. Q29983
Gene Alias DAMA-345G11.2; HLA class I antigen; MHC class I chain-related protein A; MHC class I polypeptide-related sequence A; MHC class I related sequence A; MICA; MIC-A; PERB11.1; stress inducible class I homolog; truncated MHC class I polypeptide-related sequence A
Gene Symbols MICA
Host Species Mouse
Immunogen Recombinant protein within human MICA aa 200-300.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100507436
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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