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Invitrogen™ MICAL3 Polyclonal Antibody
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Catalog No. PIPA565130
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100 μL
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PIPA565130 100 μL
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Catalog No. PIPA565130 Supplier Invitrogen™ Supplier No. PA565130
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MELASGAPRPR KASSAPSQGK ERRPDSPTRP TLRGSEEPTL KHEATSEEVL SPPSDSGGPD GSFTSSEGSS GKSKKRSSLF SPRRNKKEKK Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 75%.

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen MICAL3
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MICAL3
Gene Accession No. Q7RTP6
Gene Alias [F-actin]-monooxygenase MICAL3; flavoprotein oxidoreductase MICAL3; KIAA0819; KIAA1364; MICAL3; MICAL-3; microtubule associated monooxygenase, calponin and LIM domain containing 3; molecule interacting with CasL protein 3; protein MICAL-3; protein-methionine sulfoxide oxidase MICAL3
Gene Symbols MICAL3
Host Species Rabbit
Immunogen Recombinant Human MICAL3. Recombinant protein control fragment (Product #RP-105890).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57553
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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