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Invitrogen™ MIER3 Polyclonal Antibody
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Catalog No. PIPA531879
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100 μL
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Catalog No. Quantity
PIPA531879 100 μL
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Catalog No. PIPA531879 Supplier Invitrogen™ Supplier No. PA531879
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A431. Predicted reactivity: Mouse (93%), Rat (93%), Chimpanzee (99%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MIER3, known as Mesoderm Induction Early Response 1, Family Member 3, is a gene associated with epithelial-mesenchymal transition (EMT) processes particularly in cancer research. The gene is located on chromosome 7 and has been identified in studies as playing a crucial role in the progression of colorectal and breast cancers. Structurally, MIER3 is involved in chromatin remodeling and histone acetylation, functioning together with HDAC1/2 and Snail proteins. Its expression profile has been characterized using bioinformatics, real-time PCR, and Western blotting, indicating that MIER3 interacts closely with cellular mechanisms that modulate gene expression and cellular differentiation. The gene's role in cancer has been explored through its capacity to induce EMT, which affects tumor metastasis and cell migration, highlighting its potential as a therapeutic target in oncology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MIER3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.58 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene MIER3
Gene Accession No. Q3UHF3, Q7Z3K6
Gene Alias 5730509D14; AU015422; D130064H19Rik; mesoderm induction early response 1, family member 3; mesoderm induction early response protein 3; MIER family member 3; Mier3; Mi-er3; RGD1311241
Gene Symbols MIER3
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human MIER3. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 166968, 218613, 310086
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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