Invitrogen™ MIER3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564251

Catalog No. PIPA564251

Description

Immunogen sequence: VPESFMNEVS VNNLGVDFEN HTHHITSAKM AVSVADFGSL SANETNGFIS AHALHQHAAL HSE Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.

MIER3, known as Mesoderm Induction Early Response 1, Family Member 3, is a gene associated with epithelial-mesenchymal transition (EMT) processes particularly in cancer research. The gene is located on chromosome 7 and has been identified in studies as playing a crucial role in the progression of colorectal and breast cancers. Structurally, MIER3 is involved in chromatin remodeling and histone acetylation, functioning together with HDAC1/2 and Snail proteins. Its expression profile has been characterized using bioinformatics, real-time PCR, and Western blotting, indicating that MIER3 interacts closely with cellular mechanisms that modulate gene expression and cellular differentiation. The gene's role in cancer has been explored through its capacity to induce EMT, which affects tumor metastasis and cell migration, highlighting its potential as a therapeutic target in oncology.

Specifications

• Antigen: MIER3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MIER3
• Gene Alias: 5730509D14; AU015422; D130064H19Rik; mesoderm induction early response 1, family member 3; mesoderm induction early response protein 3; MIER family member 3; Mier3; Mi-er3; RGD1311241
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 166968
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q7Z3K6
• Gene Symbols: MIER3
• Immunogen: Recombinant protein corresponding to Human MIER3. Recombinant protein control fragment (Product #RP-103615).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov