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Invitrogen™ MIER3 Polyclonal Antibody
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Catalog No. PIPA564251
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100 μL
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PIPA564251 100 μL
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Catalog No. PIPA564251 Supplier Invitrogen™ Supplier No. PA564251
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VPESFMNEVS VNNLGVDFEN HTHHITSAKM AVSVADFGSL SANETNGFIS AHALHQHAAL HSE Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.

MIER3, known as Mesoderm Induction Early Response 1, Family Member 3, is a gene associated with epithelial-mesenchymal transition (EMT) processes particularly in cancer research. The gene is located on chromosome 7 and has been identified in studies as playing a crucial role in the progression of colorectal and breast cancers. Structurally, MIER3 is involved in chromatin remodeling and histone acetylation, functioning together with HDAC1/2 and Snail proteins. Its expression profile has been characterized using bioinformatics, real-time PCR, and Western blotting, indicating that MIER3 interacts closely with cellular mechanisms that modulate gene expression and cellular differentiation. The gene's role in cancer has been explored through its capacity to induce EMT, which affects tumor metastasis and cell migration, highlighting its potential as a therapeutic target in oncology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MIER3
Applications ChIP Assay, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MIER3
Gene Accession No. Q7Z3K6
Gene Alias 5730509D14; AU015422; D130064H19Rik; mesoderm induction early response 1, family member 3; mesoderm induction early response protein 3; MIER family member 3; Mier3; Mi-er3; RGD1311241
Gene Symbols MIER3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human MIER3. Recombinant protein control fragment (Product #RP-103615).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 166968
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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