Invitrogen™ MIF Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA582117

Catalog No. PIPA582117

Description

Immunogen sequence: FIVNTNVPRA SVPDGFLSEL TQQLAQATGK PPQYIAVHVV PDQLMAFGGS SEPCALCSLH SIGKIGGAQN RSYSKLLCGL LAERLRISPD RVYINYYDMN AANVGWNN.

MIF (macrophage migration inhibitory factor) was one of the first cytokine activities to be discovered and was initially described as a T cell-derived factor that inhibits the random migration of macrophages (Weiser 1989). Recently, MIF was rediscovered as a pituitary hormone that act as the counterregulatory hormone for glucocorticoid action within the immune system (Bernhagen 1993, Mitchell 1995). MIF was released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secreted MIF counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production (Bucala 1998). MIF plays a critical role in the host control of inflammation and immunity.

Specifications

• Antigen: MIF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Mif
• Gene Alias: cytokine; delayed early response protein 6; DER6; GIF; GLIF; glutathione-binding 13 kDa protein; Glycosylation-inhibiting factor; HGNC:7097; L-dopachrome isomerase; L-dopachrome tautomerase; macrophage migration inhibitory factor; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MGC107654; Mif; MMIF; phenylpyruvate tautomerase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17319, 4282, 81683
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.11 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P14174, P30904, P34884
• Gene Symbols: Mif
• Immunogen: Recombinant protein corresponding to Human MIF. Recombinant protein control fragment (Product #RP-91534).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG