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Invitrogen™ MINA53 Polyclonal Antibody
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Catalog No. PIPA531300
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100 μL
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PIPA531300 100 μL
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Catalog No. PIPA531300 Supplier Invitrogen™ Supplier No. PA531300
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Raji, Jurkat, A431, 293T. Predicted reactivity: Mouse (81%), Rat (84%), Rhesus Monkey (97%), Bovine (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MINA53
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.89 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene RIOX2
Gene Accession No. Q8IUF8
Gene Alias 1810047J07Rik; 2410057H13Rik; 3830408E23Rik; 60S ribosomal protein L27a histidine hydroxylase; AI449204; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; DKFZp762O1912; FLJ14393; histone lysine demethylase MINA; MDIG; mina; mina {ECO:0000312; Mina53; Mina-53; mineral dust induced gene protein; mineral dust-induced gene protein; MYC induced nuclear antigen; myc-induced nuclear antigen; myc-induced nuclear antigen, 53 kDa; NO52; Nucleolar protein 52; Protein mina53; RGD:708521}; Ribosomal oxygenase 2; Ribosomal oxygenase MINA; RIOX2; ROX
Gene Symbols RIOX2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human MINA53. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84864
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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