Invitrogen™ MINA53 Recombinant Rabbit Monoclonal Antibody (4E6G6)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538013

Catalog No. PIMA538013

Description

Positive Samples: BxPC-3, Mouse testis, Rat testis Immunogen sequence: LSTPGGKLPR LDSVVRLQFK DHIVLTVLPD QDQSDEAQEK MVYIYHSLKN SRETHMMGNE EETEFHGLRF PLSHLDALKQ IWNSPAISVK DLKLTTDEEK E.

MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.

Specifications

• Antigen: MINA53
• Classification: Recombinant Monoclonal
• Concentration: 2.2 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8CD15, Q8CFC1, Q8IUF8
• Gene Symbols: RIOX2
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human RIOX2/MINA53 (Q8IUF8).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 4E6G6
• Conjugate: Unconjugated
• Gene: RIOX2
• Gene Alias: 1810047J07Rik; 2410057H13Rik; 3830408E23Rik; 60S ribosomal protein L27a histidine hydroxylase; AI449204; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; DKFZp762O1912; FLJ14393; histone lysine demethylase MINA; MDIG; mina; mina {ECO:0000312; Mina53; Mina-53; mineral dust induced gene protein; mineral dust-induced gene protein; MYC induced nuclear antigen; myc-induced nuclear antigen; myc-induced nuclear antigen, 53 kDa; NO52; Nucleolar protein 52; Protein mina53; RGD:708521}; Ribosomal oxygenase 2; Ribosomal oxygenase MINA; RIOX2; ROX
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 266670, 67014, 84864
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov