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MIOS Mouse anti-Human, Mouse, Rat, Clone: 955413, R&D Systems™

Mouse Monoclonal Antibody

$113.85 - $339.00

Specifications

Antigen MIOS
Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.
Format Purified
Clone 955413
Applications Western Blot
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
MAB9289SP View Documents R&D Systems
MAB9289SP
25 ug Each for $113.85
Add to cart
 
MAB9289100 View Documents R&D Systems
MAB9289100
100 ug Each for $339.00
Add to cart
 
Description

Description

MIOS is a member of the octameric GATOR (GTPase-activating protein (GAP) activity toward RAGs) complex. MIOS and fellow GATOR2 subcomplex members WDR24, WDR59, SEH1Land SEC13 inhibit GATOR1 subcomplex members DEPDC5, NPRL2 and NPRL3. This inhibition by GATOR2 positively regulates mTORC1 signaling, an activity modulated by energy levels, growth factors, and amino acids. Human MIOS is 875 amino acids (aa) in length, and contains six N-terminal WD40 repeats and a C-terminal zinc finger-like domain. Over aa 620-875, human MIOS shares 98% identity with mouse and rat MIOS.
Specifications

Specifications

MIOS
Purified
Western Blot
Mouse
Protein A or G purified from hybridoma culture supernatant
RUO
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.
955413
Unconjugated
IgG1
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
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