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  5. Tocris Bioscience™ Mirabegron

Tocris Bioscience™ Mirabegron
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Catalog No. 70705
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25 mg
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Catalog No. Quantity
70-705 5 mg
70-702-5 25 mg
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Catalog No. 70-705 Supplier Tocris Bioscience™ Supplier No. 7070/5
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Description

Potent and selective β3 agonist

Mirabegron is a potent and selective β3-adrenoceptor agonist (EC50 = 22.4 nM). Displays >440-fold selectivity for β3 over β1 and β2 adrenoceptors. Increases cAMP concentration in CHO cells expressing human β3-adrenoceptor. Displays relaxant effect in ex vivo rat bladder muscle preparation precontracted with carbachol (Cat. No. 2810). Decreases frequency of bladder contraction in rats. Also promotes browning of white adipose tissue, reduces body weight, and improves glucose tolerance and insulin sensitivity in mice fed a high fat diet.

Specifications

Chemical Name or Material 2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide
CAS 223673-61-8
Quantity 5 mg
Molecular Formula C21H24N4O2S
Purity 98%
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