Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ Miro1 Reducer

Tocris Bioscience™ Miro1 Reducer
GREENER_CHOICE

Catalog No. 709110
Change view
Click to view available options
Quantity:
10 mg
50 mg
Catalog No. Quantity
70-911-0 10 mg
70-915-0 50 mg
2 options
This item is not returnable. View return policy

Catalog No. 70-911-0

Supplier: Tocris Bioscience™ 7091/10

Only null left
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Promotes mitochondrial Rho GTPase 1 (Miro1) degradation

Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.

Specifications

Chemical Name or Material N-(3-Fluorophenyl)-N'-[4-[[6-(1 H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride
Quantity 10 mg
Target Rhot1
Molecular Formula C20H16FN7O.HCl
Purity 0.98
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.