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  5. Tocris Bioscience™ Miro1 Reducer

Tocris Bioscience™ Miro1 Reducer
GREENER_CHOICE

Catalog No. 709110
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Promotes mitochondrial Rho GTPase 1 (Miro1) degradation

Miro1 Reducer is a promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.

Specifications

Chemical Name or Material N-(3-Fluorophenyl)-N'-[4-[[6-(1 H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride
Quantity 10 mg
Target Rhot1
Molecular Formula C20H16FN7O.HCl
Purity 0.98
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