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MiTF Monoclonal Antibody (D5), Invitrogen™

Catalog No. PIMA514154
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500 μL
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Catalog No. Quantity
PIMA514154 500 μL
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Catalog No. PIMA514154 Supplier Thermo Scientific Supplier No. MA514154

Description

Mouse Monoclonal Antibody

MA5-14154 targets Microphthalmia-Transcription Factor in GS and IHC (P) applications and shows reactivity with Canine and Human samples. The MA5-14154 immunogen is n-terminal fragment of human Mi protein.

Mi is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52 kDa and 56 kDa, while the longer Mi form runs as a cluster of bands at 60-70 kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MiTF
Applications Gel Shift, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone D5
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene MITF
Gene Accession No. O75030
Gene Alias BCC2; Bhlhe32; black eyed white; bw; Class E basic helix-loop-helix protein 32; CMM8; Gsfbcc2; melanocyte inducing transcription factor; melanogenesis associated transcription factor; mi; microphtalmia-associated transcription factor; microphthalmia; microphthalmia associated transcription factor isoform M-; microphthalmia transcription factor; microphthalmia-associated transcription factor; microphthalmia-associated transcription factor A; microphthalmia-associated transcription factor isoform H; microphthalmia-associated transcription factor isoform H protein; microphthalmia-associated transcription factor Trnc-1; microphthalmia-associated transcription factor Trnc-2; microphthalmia-associated transcription factor variant 1; microphthalmia-associated transcription factor variant 2; microphthalmia-associated transcription factor variant 3; microphthalmia-associated transcription factor variant MITF-M(+); MITF; MITF-H; MITF-M; MITF-M-; transcription factor, isoform 7; vit; Vitiligo; Wh; WS2; WS2A
Gene Symbols MITF
Host Species Mouse
Immunogen N-terminal fragment of human Mi protein
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 415126, 4286
Target Species Canine, Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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