MITF Recombinant Mouse Monoclonal Antibody, AbFlex™, Active Motif™

Catalog No.	Quantity
50-199-3861	100 μg
50-199-3862	10 μg

Catalog No. 50-199-3861 Supplier Active Motif Supplier No. 91201

Description

Mouse Recombinant Monoclonal Antibody

Mi is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52 kDa and 56 kDa, while the longer Mi form runs as a cluster of bands at 60-70 kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.

Specifications

• Antigen: MITF
• Applications: ChIP sequencing (ChIP-seq)
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 140mM HEPES, 35mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5
• Gene: MITF
• Gene Accession No.: O75030
• Gene Alias: BCC2; BHLHE32; black eyed white; BOS_20839; Bw; Class E basic helix-loop-helix protein 32; CMM8; Gsfbcc2; melanocyte inducing transcription factor; melanogenesis associated transcription factor; Mi; microphtalmia-associated transcription factor; microphthalmia transcription factor; Microphthalmia-associated transcription factor; microphthalmia-associated transcription factor A; microphthalmia-associated transcription factor isoform H protein; microphthalmia-associated transcription factor Trnc-1; microphthalmia-associated transcription factor Trnc-2; microphthalmia-associated transcription factor variant 1; microphthalmia-associated transcription factor variant 2; microphthalmia-associated transcription factor variant 3; microphthalmia-associated transcription factor variant MITF-M(+); MITF; MITF-H; MITF-M; transcription factor, isoform 7; Vit; Vitiligo; Wh; WS2; WS2A
• Gene Symbols: MITF
• Host Species: Mouse
• Immunogen: This antibody was raised against an N-terminal fragment of human MITF (Micropthalmia Transcription Factor).
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4286
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a