Mitomycin C, PROMO, Thermo Scientific Chemicals

Description

Mitomycin C is a methylazirinopyrroloindoledione compound showing antineoplastic and antibiotic activities. It is active against a broad-spectrum of gram-positive, gram-negative, and acid-fast bacilli bacteria.

General Description

• Mitomycin C is a methylazirinopyrroloindoledione compound isolated from the bacterium Streptomyces caespitosus, and other Streptomyces bacterial species that has antineoplastic and antibiotic activities
• This compound acts as an inhibitor of DNA synthesis, nuclear division, as well as an apoptosis inducer. It can create oxygen radicals, and produce inter-strand DNA crosslinks, inhibiting DNA synthesis
• Mitomycin C shows alkylating activity and mainly targets the guanine nucleoside sequence 5'-CpG-3'. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. Consequently, this interaction prevents the separation of complementary DNA strands, inhibiting DNA replication

Application

• Mitomycin C is active against a broad-spectrum of gram-positive, gram-negative, and acid-fast bacilli bacteria
• Mitomycin C has strong antineoplastic activity, mainly against Ehrlich ascites tumor cell lines
• This compound can inhibit B and T cells and macrophage proliferation. It can also impair antigen presentation, as well as the secretion of interferon-γ, TNF- α, and IL-2
• This compound is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems
• It has been used to treat basal-like cancer cell line in vitro experiments
• It is particularly toxic to hypoxic cells inhibiting RNA and protein synthesis at high concentrations

Specifications

Chemical Identifiers

• CAS: 50-07-7
• Molecular Formula: C15H18N4O5
• Molecular Weight (g/mol): 334.33 g/mol
• MDL Number: MFCD00078109
• InChI Key: NWIBSHFKIJFRCO-WUDYKRTCSA-N
• PubChem CID: 5746
• ChEBI: CHEBI:27504
• SMILES: CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N

• Type: Mitomycin C
• Physical Form: Powder
• Melting Point: 360°C
• Color: Blue to Purple
• Quantity: 10 mg
• UN Number: UN2811
• Beilstein: 7231816
• Merck Index: 14,6215
• Solubility Information: Soluble in methanol, water and dimethyl sulfoxide.
• Chemical Name or Material: Mitomycin C

Safety and Handling

DOTInformation	Transport Hazard Class: 6.1; Packing Group: II; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	200-008-6
RTECSNumber	CN0700000
TSCA	Yes
Recommended Storage	Keep cold

RUO - Research Use Only