Invitrogen™ MKNK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5111659

Catalog No. PIPA5111659

Description

Immunogen sequence: AIAMNRQLAQ HDEDLAEEEA AGQGQPVLVR ATSRCLQLSP PSQSKLAQ.

The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases, regulate protein synthesis by phosphroylation eIF4E on Ser209, and may contribute to tumorigenesis. Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94% identical) and human Mnk1 (71% identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta.

Specifications

• Antigen: MKNK2
• Classification: Polyclonal
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9HBH9
• Gene Symbols: Mknk2
• Immunogen: Recombinant Protein corresonding to Human MKNK2. Recombinant protein control fragment (Product #RP-106497).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunocytochemistry
• Conjugate: Unconjugated
• Gene: Mknk2
• Gene Alias: 2010016G11Rik; G protein-coupled receptor kinase 7; GPRK7; MAP kinase interacting serine/threonine kinase 2; MAP kinase signal-integrating kinase 2; MAP kinase-interacting serine/threonine kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 2; MAPK interacting serine/threonine kinase 2; MAPK signal-integrating kinase 2; Mknk2; MNK2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2872
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid